Pulmonary haemorrhage as a frequent cause of death among patients with severe complicated Leptospirosis in Southern Sri Lanka.
Chathuranga Lakmal FonsekaNiroshana Jathun DahanayakeDenagama J D MihiranKalani Mithunika WijesingheLakshani Nawanjana LiyanageHesaru S WickramasuriyaGaya Bandara WijayaratneKelum SanjayaChampica K BodinayakePublished in: PLoS neglected tropical diseases (2023)
Within first 48 hours of admission, major complications such as pulmonary haemorrhage and haemodynamic instability and other parameters such as atrial fibrillation, acute haemoglobin reduction, elevated SGOT level could be used as early parameters predictive of mortality in severe leptospirosis. PH and FHF during the first week of admission in leptospirosis are associated with high morbidity and mortality requiring prolonged ICU care and hospitalisation. Above parameters could be used as parameters indicating severity for triaging and intensifying treatment. Using ECMO is a plausible treatment option in patients with severe pulmonary haemorrhage.
Keyphrases
- pulmonary hypertension
- atrial fibrillation
- early onset
- emergency department
- healthcare
- drug induced
- intensive care unit
- palliative care
- respiratory failure
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome
- randomized controlled trial
- cardiovascular disease
- type diabetes
- cardiovascular events
- hepatitis b virus
- left atrial
- percutaneous coronary intervention
- combination therapy
- catheter ablation
- study protocol
- acute coronary syndrome
- left ventricular
- left atrial appendage
- pain management
- venous thromboembolism
- smoking cessation