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Structural and biological survey of 7-chloro-4-(piperazin-1-yl)quinoline and its derivatives.

Aida M Abd El-Sattar El-AzzounyMohamed Nabil Aboul-EneinMohamed Farouk Hamissa
Published in: Drug development research (2020)
The 7-chloro-4-(piperazin-1-yl)quinoline structure is an important scaffold in medicinal chemistry. It exhibited either alone or as hybrid with other active pharmacophores diverse pharmacological profiles such as: antimalarial, antiparasitic, anti-HIV, antidiabetic, anticancer, sirtuin Inhibitors, dopamine-3 ligands, acetylcholinesterase inhibitors, and serotonin antagonists. In the presented review, a comprehensive discussion of compounds having this structural core is surveyed and illustrated.
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