Insomnia symptom severity and cognitive performance: Moderating role of APOE genotype.
Andrée-Ann BarilAlexa S BeiserErlan SanchezVincent MysliwiecSusan RedlineDaniel J GottliebGeorge T O'ConnorMitzi M GonzalesDibya HimaliSudha SeshadriJayandra J HimaliMatthew P PasePublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2021)
Insomnia symptom severity was associated with worse subsequent global cognitive and memory performance, which was especially apparent in APOE ε4 allele carriers, suggesting that poor sleep might be particularly detrimental when the brain is already vulnerable to neurodegeneration.
Keyphrases
- sleep quality
- cognitive decline
- high fat diet
- white matter
- resting state
- physical activity
- working memory
- depressive symptoms
- social support
- mild cognitive impairment
- adipose tissue
- functional connectivity
- diffusion weighted imaging
- type diabetes
- insulin resistance
- magnetic resonance imaging
- metabolic syndrome
- computed tomography