Effects of Ibudilast on Retinal Atrophy in Progressive Multiple Sclerosis Subtypes: Post-Hoc Analyses of the SPRINT-MS Trial.
Henrik EhrhardtJeffrey LambeHussein MoussaEleni S VasileiouGrigorios KalaitzidisOlwen C MurphyAngeliki G FilippatouNicole PellegriniMorgan DouglasSimidele DavisNatalia NagyAgustina QuirogaChen HuAlexandra Zambriczki LeeAnna DuvalKathryn C FitzgeraldJerry L PrincePeter A CalabresiElias S SotirchosRobert BermelShiv SaidhaPublished in: Neurology (2023)
This study provides Class II evidence that ibudilast reduces composite ganglion cell and inner plexiform layer atrophy, without reduction of inner or outer nuclear layer atrophy, in patients with progressive MS but not those with secondary progressive MS.
Keyphrases
- multiple sclerosis
- white matter
- mass spectrometry
- single cell
- optical coherence tomography
- study protocol
- clinical trial
- cell therapy
- optic nerve
- diabetic retinopathy
- randomized controlled trial
- ms ms
- neuropathic pain
- stem cells
- high intensity
- spinal cord injury
- spinal cord
- mesenchymal stem cells
- bone marrow
- body composition