Six gene and TH2 signature expression in endobronchial biopsies of participants with asthma.

Stephany Sánchez-Ovando Katherine Joanne BainesDaniel BarkerPeter A B Wark Jodie L Simpson

Published in: Immunity, inflammation and disease (2020)

There was increased expression of DNASE1L3 in asthma and IL1B in neutrophilic asthma. These results show similar upregulated patterns of expression in two genes of the 6GS in endobronchial biopsies, previously identified in sputum. The upregulation of DNASE1L3 and IL1B suggests that common mechanisms may be at play throughout the airway.

Keyphrases

poor prognosis
chronic obstructive pulmonary disease
ultrasound guided
lung function
genome wide
allergic rhinitis
signaling pathway
gene expression
dna methylation
air pollution