Heat shock protein 70 dampens the inflammatory response of human PDL cells to mechanical loading in vitro.
Jana MarciniakStefan LossdörferChristian KirschneckJames DeschnerAndreas JägerMichael WolfPublished in: Journal of periodontal research (2019)
The results indicate a regulatory role for HSP70 in the control of the inflammatory hPDL cell response to mechanical loading and identify HSP70 as a target in the attempt to attenuate tissue damage during orthodontic tooth movement. Furthermore, the present findings point to the risk of increased periodontal destruction when medication targeting HSP70 is applied for severe medical conditions during orthodontic tooth movement.
Keyphrases
- heat shock protein
- inflammatory response
- heat shock
- induced apoptosis
- oxidative stress
- healthcare
- endothelial cells
- oral health
- cell cycle arrest
- single cell
- transcription factor
- lipopolysaccharide induced
- cell therapy
- early onset
- induced pluripotent stem cells
- endoplasmic reticulum stress
- pluripotent stem cells
- lps induced
- drug delivery
- drug induced