The role of double-strand break repair, translesion synthesis, and interstrand crosslinks in colorectal cancer progression-clinicopathological data and survival.

Gustavo Andreazza LaporteNatália M LeguisamoHelena de Castro E GloriaDaniel B AzambujaAntonio N KalilJenifer Saffi

Published in: Journal of surgical oncology (2019)

This study demonstrated that low expression or unmethylated POLH and POLK were related to worse biological behavior tumors. However, POLK methylation was associated with better DFS. POLK and POLH are potential prognostic biomarkers in CRC.

Keyphrases

poor prognosis
dna methylation
electronic health record
big data
binding protein