Preclinical Studies with Glioblastoma Brain Organoid Co-Cultures Show Efficient 5-ALA Photodynamic Therapy.

Leire Pedrosa Carmen Bedia Diouldé DiaoAlejandra MosteiroAbel Ferrés Elisabetta Stanzani Fina Martínez-Soler Avelina Tortosa Estela Pineda Losada Iban AldecoaMarc CentellasMarta Muñoz-Tudurí Ana Sevilla Angels SierraJosé Juan González Sánchez

Published in: Cells (2023)

We provide evidence about the effectiveness of PDT to treat high proliferative GB cells in a complex in vitro system, which combines normal and cancer cells and is a useful tool to standardize new strategic therapies.

Keyphrases

photodynamic therapy
induced apoptosis
fluorescence imaging
cell cycle arrest
randomized controlled trial
systematic review
white matter
oxidative stress
resting state
endoplasmic reticulum stress
cell therapy
stem cells
functional connectivity
blood brain barrier