Impact of Preeclampsia on the Relationship between Maternal Asthma and Offspring Asthma. An Observation from the VDAART Clinical Trial.
Hooman MirzakhaniVincent J CareyThomas F McElrathWeiliang QiuBruce W HollisGeorge T O'ConnorRobert S ZeigerLeonard BacharierAugusto A LitonjuaScott T WeissPublished in: American journal of respiratory and critical care medicine (2019)
Preeclampsia is associated with increased risk of early life childhood asthma in children less than 3 years old over and above that associated with maternal asthma alone. The results implicate the interplay between maternal factors as strong predictors of offspring asthma and in utero maternal-fetal immune perturbations and developmental dysregulations associated with preeclampsia.
Keyphrases
- chronic obstructive pulmonary disease
- pregnancy outcomes
- lung function
- early life
- allergic rhinitis
- clinical trial
- birth weight
- early onset
- high fat diet
- pregnant women
- young adults
- cystic fibrosis
- type diabetes
- randomized controlled trial
- air pollution
- metabolic syndrome
- physical activity
- adipose tissue
- weight gain
- skeletal muscle
- weight loss