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Cytotoxic Potential, Metabolic Profiling, and Liposomes of Coscinoderma sp. Crude Extract Supported by in silico Analysis.

Arafa MusaAbeer H ElmaidomyAhmed M SayedSami I AlzareaMohammad M Al-SaneaEhab M MostafaOmina Magdy HendawyMohamed Abdelwahab AbdelgawadKhayrya A YoussifHesham RefaatEman AlaaeldinUsama Ramadan Abdelmohsen
Published in: International journal of nanomedicine (2021)
Encapsulation of both the hydrophilic and the lipophilic components of the extract within the lipid-based nanovesicles enhanced the cellular uptake and accessibility of the entrapped cargo. This study introduces liposomal nano-vesicles as a promising approach to improve the therapeutic potential of sponge-derived extracts.
Keyphrases
  • oxidative stress
  • drug delivery
  • anti inflammatory
  • single cell
  • liquid chromatography
  • fatty acid
  • mass spectrometry
  • risk assessment
  • molecular dynamics simulations
  • tandem mass spectrometry