Nano-hydroxyapatite as a delivery system: overview and advancements.
Muhammad Usman MunirSajal SalmanIbrahim JavedSyed Nasir Abbas BukhariNaveed AhmadNaveed Akhter ShadFarooq AzizPublished in: Artificial cells, nanomedicine, and biotechnology (2022)
Nano-hydroxyapatite is being investigated as vital components of implants and dental and tissue engineering devices. It is found as a bone replacement due to its non-toxicity and cytocompatibility with dental tissues and bone. The reality that nanocrystalline hydroxyapatite can be made of porous granules and scaffolds. Additionally, it has a massive loading potential indicating its use as a transporter for drugs or a regulated drug release mechanism in pharmaceutical research. This review aims to present existing nano-hydroxyapatite research developments as a drug carrier employed in bone tissue disorders locally and deliver poorly soluble drugs with reduced bioavailability. We have discussed the nano-hydroxyapatite role in the delivery of drugs (i.e. anti-resorptive, anti-cancer, and antibiotics), proteins, genetic material, and radionuclides.
Keyphrases
- tissue engineering
- bone regeneration
- drug release
- bone mineral density
- soft tissue
- oral health
- gene expression
- oxidative stress
- emergency department
- genome wide
- transcription factor
- body composition
- lactic acid
- mass spectrometry
- dna methylation
- climate change
- risk assessment
- copy number
- atomic force microscopy
- high resolution
- high speed
- virtual reality