Expression of PD-L1 and other immunotherapeutic targets in thymic epithelial tumors.
Kathryn C ArbourJarushka NaidooKeith E SteeleAi NiAndre L MoreiraNatasha RekhtmanPaul B RobbinsJoyson KarakunnelAndreas RimnerJames HuangGregory J RielyMatthew D HellmannPublished in: PloS one (2017)
TETs are characterized by frequent PD-L1 expression and PD-L1 is associated with improved survival, suggesting PD-L1 signaling may be biologically important in TETs. Robust expression of markers of immune activation and immunotherapeutic target molecules in TETs emphasizes the potential for development of anti-PD-1/PD-L1 therapies.