The effect of psychoactive bacteria, Bifidobacterium longum Rosell®-175 and Lactobacillus rhamnosus JB-1, on brain proteome profiles in mice.
Łukasz Sebastian JaroszKatarzyna SocałaKatarzyna MichalakAdrian WiaterArtur CiszewskiMałgorzata MajewskaAgnieszka MarekZbigniew GrądzkiPiotr WlaźPublished in: Psychopharmacology (2023)
The psychobiotics Bifidobacterium longum Rosell®-175 and Lactobacillus rhamnosus JB-1enhances expression of proteins involved in the activation and maturation of nerve cells, as well as myelination and homeostatic regulation of neurogenesis in mice. The tested psychobiotics cause a decrease in the expression of proteins associated with CNS development and in synaptic transmission, thereby reducing the capacity for communication between nerve cells. The results of the study indicate that psychobiotic bacteria can be used in auxiliary treatment of neurological disorders.
Keyphrases
- induced apoptosis
- poor prognosis
- cell cycle arrest
- endoplasmic reticulum stress
- high fat diet induced
- binding protein
- type diabetes
- long non coding rna
- blood brain barrier
- white matter
- signaling pathway
- peripheral nerve
- multiple sclerosis
- metabolic syndrome
- pi k akt
- cell proliferation
- combination therapy
- prefrontal cortex