Dexmedetomidine for Facilitating Mechanical Ventilation Extubation in Difficult-to-Wean ICU Patients: Systematic Review and Meta-Analysis of Clinical Trials.
Mitchell S BuckleyPamela L SmithburgerAdrian WongGilles L FraserMichael C ReadeMichele Klein-FedyshinThomas ArdilesSandra L Kane-GillPublished in: Journal of intensive care medicine (2020)
Dexmedetomidine was associated with a significant reduction in the time to extubation and shorter ICU stay in difficult-to-wean ICU patients. Although hypotension risk was increased with dexmedetomidine, no differences in other clinical outcomes were observed.
Keyphrases
- acute kidney injury
- cardiac surgery
- mechanical ventilation
- intensive care unit
- systematic review
- end stage renal disease
- clinical trial
- acute respiratory distress syndrome
- ejection fraction
- newly diagnosed
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- randomized controlled trial
- respiratory failure
- patient reported outcomes
- extracorporeal membrane oxygenation
- meta analyses
- study protocol
- double blind
- open label
- phase ii