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Type XXVIII Collagen Regulates Renal Interstitial Fibrosis and Epithelial-Mesenchymal Transition by SREBP1-Mediated HKDC1 Expression.

Linlin LiQi ZouBinbin LiLushi HuangLixin Wei
Published in: Journal of the renin-angiotensin-aldosterone system : JRAAS (2022)
Overexpression of COL28 can aggravate renal interstitial fibrosis by encouraging renal tubular epithelial cells to undergo EMT, and interference with HKDC1 expression can alleviate fibrosis by reversing EMT induced by COL28 overexpression.
Keyphrases
  • epithelial mesenchymal transition
  • poor prognosis
  • transforming growth factor
  • cell proliferation
  • transcription factor
  • liver fibrosis
  • long non coding rna
  • endothelial cells