Elevated expression of HIGD1A drives hepatocellular carcinoma progression by regulating polyamine metabolism through c-Myc-ODC1 nexus.
Haixing ZhangXiaoran LiZiying LiuZimo LinKuiyuan HuangYiran WangYu ChenLeyi LiaoLeyuan WuZhanglian XieJin-Lin HouXiaoyong ZhangHongyan LiuPublished in: Cancer & metabolism (2024)
Our results demonstrated that HIGD1A activated c-Myc-ODC1 nexus to regulate polyamine synthesis and to promote HCC survival and malignant phenotype, implying that HIGD1A might represent a novel therapeutic target for HCC.