Diosgenin Protects Against Kidney Injury and Mitochondrial Apoptosis Induced by 3-MCPD Through the Regulation of ER Stress, Ca2+ Homeostasis, and Bcl2 Expression.

Yujie ZhongChengni JinJiahui HanJiachang ZhuQi LiuDianjun SunXiaodong XiaYu ZhangXiaoli Peng

Published in: Molecular nutrition & food research (2021)

This study demonstrates that DIO exerts protective effect against kidney injury, mitochondrial dysfunction, and apoptosis through the inhibition of ER stress and the further maintenance of Ca2+ homeostasis and Bcl2 expression.

Keyphrases

oxidative stress
poor prognosis
endoplasmic reticulum stress
cell cycle arrest
cell death
binding protein
signaling pathway