The mGlu5 receptor negative allosteric modulator mavoglurant reduces escalated cocaine self-administration in male and female rats.
Leandro F VendruscoloJanaina C M VendruscoloKimberly E WhitingJane B AcriNora D VolkowGeorge F KoobPublished in: Psychopharmacology (2024)
These findings suggest that the mGlu5 receptor is involved in escalated cocaine self-administration. These findings support the development of clinical trials of mavoglurant to evaluate its potential therapeutic benefits for CUD.