Molecular and clinical studies in 8 patients with Temple syndrome.
G Gillessen-KaesbachB AlbrechtEggermann ThomasMiriam ElbrachtD MitterS MorlotC M A van Ravenswaaij-ArtsS SchulzG Strobl-WildemannK BuitingJasmin BeygoPublished in: Clinical genetics (2018)
Temple syndrome (TS14, #616222) is a rare imprinting disorder characterised by phenotypic features including pre- and postnatal growth retardation, muscular hypotonia and feeding difficulties in infancy, early puberty and short stature with small hands and feet and often truncal obesity. It is caused by maternal uniparental disomies, paternal deletions and primary imprinting defects that affect the chromosomal region 14q32 and lead to a disturbed expression of imprinted genes in this region. Here, we present detailed clinical data of 8 patients with Temple syndrome, 4 with an imprinting defect, 2 with an imprinting defect in a mosaic state as well as 1 complete and 1 segmental maternal uniparental disomy of chromosome 14.
Keyphrases
- case report
- birth weight
- weight gain
- metabolic syndrome
- poor prognosis
- insulin resistance
- copy number
- preterm infants
- pregnancy outcomes
- machine learning
- gene expression
- pregnant women
- high resolution
- binding protein
- single molecule
- high fat diet induced
- adipose tissue
- long non coding rna
- skeletal muscle
- growth hormone