Efficacy of Maternal Choline Supplementation During Pregnancy in Mitigating Adverse Effects of Prenatal Alcohol Exposure on Growth and Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Sandra W JacobsonR Colin CarterChristopher D MoltenoMark E StantonJane S HerbertNadine M LindingerCatherine E LewisNeil C DodgeH Eugene HoymeSteven H ZeiselErnesta M MeintjesChristopher P DugganJoseph L JacobsonPublished in: Alcoholism, clinical and experimental research (2018)
This exploratory study is the first to provide evidence that a high dose of choline administered early in pregnancy can mitigate adverse effects of heavy PAE on EBC, postnatal growth, and cognition in human infants. These findings are consistent with studies of alcohol-exposed animals that have demonstrated beneficial effects of choline supplementation on classical conditioning, learning, and memory.
Keyphrases
- double blind
- placebo controlled
- clinical trial
- high dose
- phase ii
- phase iii
- study protocol
- endothelial cells
- pregnancy outcomes
- pregnant women
- preterm infants
- alcohol consumption
- low dose
- mild cognitive impairment
- randomized controlled trial
- preterm birth
- stem cell transplantation
- phase ii study
- white matter
- weight loss
- body mass index