Proteomic and metabolomic characterization of streptozotocin-induced diabetic nephropathy in TIMP3-deficient mice.
Claudia RossiValeria MarzanoAda ConsalvoMirco ZucchelliStefano Levi MorteraViviana CasagrandeMaria MavilioPaolo SacchettaMassimo FedericiRossella MenghiniAndrea UrbaniDomenico CiavardelliPublished in: Acta diabetologica (2017)
Proteomic and metabolomic approaches showed that loss of TIMP3 alone or in combination with STZ treatment results in significant alterations of kidney lipid metabolism and peripheral acylcarnitine levels, supporting the idea that loss of TIMP3 may generate a phenotype more prone to DN.