TEAD4 functions as a prognostic biomarker and triggers EMT via PI3K/AKT pathway in bladder cancer.

Ming ChiJiao LiuChenxue MeiYaxing ShiNanqi LiuXuefeng JiangChang LiuNan XueHong HongJisheng XieXun SunBo YinXin MengBiao Wang

Published in: Journal of experimental & clinical cancer research : CR (2022)

TEAD4 is closely correlated with poor prognosis in BLCA and mediates its metastasis through regulating EMT via PI3K/AKT pathway, proving that TEAD4 is not only an effective biomarker for predicting the prognosis but also a great potential target for treatment of metastatic BLCA.

Keyphrases

poor prognosis
long non coding rna
epithelial mesenchymal transition
small cell lung cancer
squamous cell carcinoma
human health
risk assessment
replacement therapy
smoking cessation
muscle invasive bladder cancer