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Protocol for the Incorporation of γ-Amino Acids into Peptides: Application to (-)-Shikimic Acid Based 2-Amino-Methylcyclohexanecarboxylic Acids.

Marcos A GonzálezAmalia M EstévezMaría CamposJuan C EstévezRamón J Estévez
Published in: The Journal of organic chemistry (2018)
The first example of a new protocol for the incorporation of γ-amino acids into peptides is reported. It involved a shikimic acid based stereoselective synthesis polyhydroxylated-2-nitromethylcyclohexanecarboxylic acids, which were directly incorporated into peptides.
Keyphrases
  • amino acid
  • randomized controlled trial