Cell-surface antigen profiling of pediatric brain tumors: B7-H3 is consistently expressed and can be targeted via local or systemic CAR T-cell delivery.

Dalia HaydarHaley HoukeJason ChiangZhongzhen YiZelda OdéKenneth CaldwellXiaoyan ZhuKimberly S MercerJennifer L StripayTimothy I ShawPeter VogelChristopher DeRenzoSuzanne J BakerMartine F RousselStephen GottschalkGiedre Krenciute

Published in: Neuro-oncology (2021)

Our study highlights the importance of studying target antigen and HLA class I expression in PDOX samples for the future design of immunotherapies. In addition, our results support active preclinical and clinical exploration of B7-H3-targeted CAR T-cell therapies for a broad spectrum of pediatric brain tumors.

Keyphrases

cell surface
cancer therapy
poor prognosis
current status
single cell
binding protein
bone marrow