17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson's disease are associated with LRRC37A/2 expression in astrocytes.
Kathryn R BowlesDerian A PughYiyuan LiuTulsi PatelAlan E RentonSara Bandres-CigaZiv Gan-OrPeter HeutinkAri SiitonenSarah BertelsenJonathan D CherryCeleste M KarchSteven J FruchtBrian H KopellInga PeterY J Parknull nullAlexander CharneyTowfique RajJohn F CraryA M GoatePublished in: Molecular neurodegeneration (2022)
These data indicate that a novel candidate gene, LRRC37A/2, contributes to the association between the 17q21.31 locus and PD via its interaction with α-synuclein and its effects on astrocytic function and inflammatory response. These data are the first to associate the genetic association at the 17q21.31 locus with PD pathology, and highlight the importance of variation at the 17q21.31 locus in the regulation of multiple genes other than MAPT and KANSL1, as well as its relevance to non-neuronal cell types.
Keyphrases
- inflammatory response
- genome wide
- electronic health record
- genome wide association study
- big data
- poor prognosis
- genome wide identification
- single cell
- dna methylation
- lipopolysaccharide induced
- immune response
- cerebral ischemia
- gene expression
- transcription factor
- lps induced
- toll like receptor
- binding protein
- mesenchymal stem cells
- data analysis
- genome wide analysis
- blood brain barrier