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17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson's disease are associated with LRRC37A/2 expression in astrocytes.

Kathryn R BowlesDerian A PughYiyuan LiuTulsi PatelAlan E RentonSara Bandres-CigaZiv Gan-OrPeter HeutinkAri SiitonenSarah BertelsenJonathan D CherryCeleste M KarchSteven J FruchtBrian H KopellInga PeterY J Parknull nullAlexander CharneyTowfique RajJohn F CraryA M Goate
Published in: Molecular neurodegeneration (2022)
These data indicate that a novel candidate gene, LRRC37A/2, contributes to the association between the 17q21.31 locus and PD via its interaction with α-synuclein and its effects on astrocytic function and inflammatory response. These data are the first to associate the genetic association at the 17q21.31 locus with PD pathology, and highlight the importance of variation at the 17q21.31 locus in the regulation of multiple genes other than MAPT and KANSL1, as well as its relevance to non-neuronal cell types.
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