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Effect of SGLT2 inhibitors on body composition, fluid status and renin-angiotensin-aldosterone system in type 2 diabetes: a prospective study using bioimpedance spectroscopy.

Anja SchorkJanine SaynischAndreas VosselerBenjamin Assad JaghutrizNils HeyneAndreas PeterHans-Ulrich HäringNorbert StefanAndreas FritscheFerruh Artunc
Published in: Cardiovascular diabetology (2019)
Body weight reduction under the treatment with SGLT2-inhibitors is caused by reduction of adipose tissue mass and transient loss of extracellular fluid, which is accompanied by upregulation of renin-angiotensin-aldosterone system (RAAS). Permanent loss of extracellular water does not occur under SGLT2 inhibition.
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