VPRBP Functions Downstream of the Androgen Receptor and OGT to Restrict p53 Activation in Prostate Cancer.

Ninu PouloseNicholas ForsytheAdam PolonskiGemma GreggSarah L MaguireMarc FuchsSarah MinnerGuido SauterSimon S McDade Ian Geoffrey Mills

Published in: Molecular cancer research : MCR (2022)

In conclusion, we have shown that VPRBP/DCAF1 promotes prostate cancer cell proliferation by restraining p53 activation under the influence of the AR and OGT.

Keyphrases

prostate cancer
radical prostatectomy
cell proliferation
cell cycle
signaling pathway