Oral delivery of Hyperimmune bovine serum antibodies against CS6-expressing enterotoxigenic Escherichia coli as a prophylactic against diarrhea.
Kawsar R TalaatC K PorterA L BourgeoisT K LeeC A DuplessisMilton MacielR L GutierrezB DeNearingB AdjoodaniR AdkinsonK J TestaB FeijooA N AlcalaJ BrubakerA BeselmanS ChakrabortyD SackJ HalpernS TropH WuJ JiaoEddie J SullivanM S RiddleS S JosephSteven T PooleM G ProutyPublished in: Gut microbes (2020)
. Bovine-derived serum antibodies appear safe and well tolerated. Antibodies derived from cattle immunized with whole cell B7A provided 50% protection against MSD following B7A challenge; however, no protection was observed in subjects receiving serum antibodies targeting CS6. The lack of observed efficacy in this group may be due to low CS6 surface expression on B7A, the high dose challenge inoculum and/or the use of serum derived antibodies versus colostrum-derived antibodies.