Seropositivity-Dependent Association between LINE-1 Methylation and Response to Methotrexate Therapy in Early Rheumatoid Arthritis Patients.

Amin RavaeiLia PulsatelliElisa AssirelliRiccardo MeliconiJacopo CiaffiElisa GremeseBarbara TolussoCarlo SalvaraniMarcello Govoni Michele Rubini

Published in: Genes (2022)

The LINE-1 methylation level in PBMCs of naïve ERA cases associates with the degree of response to MTX therapy in an opposite way depending on the presence of RF and ACPA antibodies. Our results suggest LINE-1 methylation level as a new epigenetic biomarker for predicting the degree of response to MTX in both double-positive and seronegative ERA patients.

Keyphrases

dna methylation
rheumatoid arthritis patients
genome wide
end stage renal disease

ejection fraction
newly diagnosed
chronic kidney disease
disease activity

gene expression
prognostic factors
peritoneal dialysis
low dose

patient reported outcomes
systemic lupus erythematosus
mesenchymal stem cells
smoking cessation