Seropositivity-Dependent Association between LINE-1 Methylation and Response to Methotrexate Therapy in Early Rheumatoid Arthritis Patients.
Amin RavaeiLia PulsatelliElisa AssirelliRiccardo MeliconiJacopo CiaffiElisa GremeseBarbara TolussoCarlo SalvaraniMarcello GovoniMichele RubiniPublished in: Genes (2022)
The LINE-1 methylation level in PBMCs of naïve ERA cases associates with the degree of response to MTX therapy in an opposite way depending on the presence of RF and ACPA antibodies. Our results suggest LINE-1 methylation level as a new epigenetic biomarker for predicting the degree of response to MTX in both double-positive and seronegative ERA patients.
Keyphrases
- dna methylation
- rheumatoid arthritis patients
- genome wide
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- disease activity
- gene expression
- prognostic factors
- peritoneal dialysis
- low dose
- patient reported outcomes
- systemic lupus erythematosus
- mesenchymal stem cells
- smoking cessation