Hybrid Nanogel Drug Delivery Systems: Transforming the Tumor Microenvironment through Tumor Tissue Editing.
Theodora KatopodiSavvas PetanidisGeorge FlorosKonstantinos PorpodisChristoforos KosmidisPublished in: Cells (2024)
The future of drug delivery offers immense potential for the creation of nanoplatforms based on nanogels. Nanogels present a significant possibility for pharmaceutical advancements because of their excellent stability and effective drug-loading capability for both hydrophobic and hydrophilic agents. As multifunctional systems, composite nanogels demonstrate the capacity to carry genes, drugs, and diagnostic agents while offering a perfect platform for theranostic multimodal applications. Nanogels can achieve diverse responsiveness and enable the stimuli-responsive release of chemo-/immunotherapy drugs and thus reprogramming cells within the TME in order to inhibit tumor proliferation, progression, and metastasis. In order to achieve active targeting and boost drug accumulation at target sites, particular ligands can be added to nanogels to improve the therapeutic outcomes and enhance the precision of cancer therapy. Modern "immune-specific" nanogels also have extra sophisticated tumor tissue-editing properties. Consequently, the introduction of a multifunctional nanogel-based drug delivery system improves the targeted distribution of immunotherapy drugs and combinational therapeutic treatments, thereby increasing the effectiveness of tumor therapy.
Keyphrases
- cancer therapy
- drug delivery
- crispr cas
- randomized controlled trial
- photodynamic therapy
- induced apoptosis
- systematic review
- drug release
- genome wide
- risk assessment
- signaling pathway
- type diabetes
- gene expression
- adverse drug
- climate change
- metabolic syndrome
- pain management
- metal organic framework
- insulin resistance
- adipose tissue
- human health
- genome wide analysis