Antiseizure Medication Use During Pregnancy and Neonatal Growth Outcomes: A Systematic Review and Meta-Analysis.

Alekhya LavuChristine VaccaroEnav ZusmanLaila AboulattaBasma AloudSilvia Alessi-SeveriniLara HaidarPayam PeymaniMarcus C NgChelsea RuthJamison FalkBrianne DesrochersEunice ValenciaWalid ShoumanRasheda RabbaniSherif Eltonsy

Published in: British journal of clinical pharmacology (2023)

This meta-analysis demonstrates that pregnant people exposed to ASMs have a significantly increased risk of adverse fetal growth outcomes including SGA and LBW and decreased birth weight compared to unexposed pregnant people. Polytherapy was associated with higher risks compared to monotherapy. Additional studies are warranted on specific ASMs risks.

Keyphrases

birth weight
systematic review
pregnant women
case control
gestational age
weight gain
human health
type diabetes
clinical trial
body mass index
physical activity
emergency department
open label
randomized controlled trial
meta analyses
combination therapy
risk assessment
preterm birth