Cytogenomic characterization of pediatric T-cell acute lymphoblastic leukemia reveals TCR rearrangements as predictive factors for exceptional prognosis.
Libuse LizcovaEva PrihodovaLenka PavlistovaKarla SvobodovaEster MejstrikovaOndrej HrusakPavla LuknarovaIveta JanotovaLucie SramkovaJan StaryZuzana ZemanovaPublished in: Molecular cytogenetics (2024)
We identified a subgroup of patients with TCR aberrations (both TRA/TRD and TRB), who had an excellent prognosis in our cohort with 5-year EFS and OS of 100%, regardless of the presence of other abnormality or the translocation partner. Our data suggest that escalation of treatment intensity, which may be considered in subsets of T-ALL is not needed for nonHR (non-high risk) patients with TCR aberrations.
Keyphrases
- regulatory t cells
- acute lymphoblastic leukemia
- copy number
- allogeneic hematopoietic stem cell transplantation
- peripheral blood
- electronic health record
- open label
- dendritic cells
- randomized controlled trial
- high intensity
- big data
- clinical trial
- gene expression
- dna methylation
- machine learning
- combination therapy
- hepatitis c virus
- artificial intelligence
- study protocol
- hiv testing
- smoking cessation
- childhood cancer