Translation of liver stage activity of M5717, a Plasmodium elongation factor 2 inhibitor: from bench to bedside.
Akash KhandelwalFrancisca ArezPaula M AlvesLassina BadoloCatarina BritoChristoph FischliDiana FontinhaClaude OeuvrayMiguel PrudêncioMatthias RottmannJustin WilkinsÖzkan YalkinogluWilhelmina M BagchusThomas SpangenbergPublished in: Malaria journal (2022)
This approach has the potential to accelerate the search for new anti-malarials, to reduce the number of healthy volunteers needed in a clinical study and decrease and refine the animal use in the preclinical phase.