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Translation of liver stage activity of M5717, a Plasmodium elongation factor 2 inhibitor: from bench to bedside.

Akash KhandelwalFrancisca ArezPaula M AlvesLassina BadoloCatarina BritoChristoph FischliDiana FontinhaClaude OeuvrayMiguel PrudêncioMatthias RottmannJustin WilkinsÖzkan YalkinogluWilhelmina M BagchusThomas Spangenberg
Published in: Malaria journal (2022)
This approach has the potential to accelerate the search for new anti-malarials, to reduce the number of healthy volunteers needed in a clinical study and decrease and refine the animal use in the preclinical phase.
Keyphrases
  • cell therapy
  • plasmodium falciparum
  • stem cells
  • clinical trial
  • risk assessment
  • bone marrow