Reduced neurosteroid potentiation of GABAA receptors in epilepsy and depolarized hippocampal neurons.
Suchitra JoshiWilliam H RodenJaideep KapurLaura A JansenPublished in: Annals of clinical and translational neurology (2020)
These findings suggest that seizure activity-induced upregulation of α4 βx γ2 subunit-containing GABARs could affect the anticonvulsant actions of neurosteroids.