Differential regulation of mRNA fate by the human Ccr4-Not complex is driven by coding sequence composition and mRNA localization.

Sarah L GillenChiara GiacomelliKelly HodgeSara ZanivanMartin BushellAnia Wilczynska

Published in: Genome biology (2021)

We define the key mRNA features that determine how the human Ccr4-Not complex differentially regulates mRNA fate and protein synthesis through a mechanism linked to codon composition, amino acid usage, and mRNA localization.

Keyphrases

endothelial cells
binding protein
amino acid
induced pluripotent stem cells
pluripotent stem cells