Proprotein convertase subtilisin kexin 9 is associated with disease activity and is implicated in immune activation in systemic lupus erythematosus.

Anquan LiuMizanur RahmanIngiäld HafströmSofia AjeganovaJohan Frostegård

Published in: Lupus (2020)

PCSK9 is associated with disease activity in SLE. One underlying cause could be OxLDL promoting DC activation which depends on PCSK9. OxLDL induces PCSK9 - an effect which is higher among SLE patients. PCSK9 could play an unexpected immunological role in SLE.

Keyphrases

disease activity
systemic lupus erythematosus
rheumatoid arthritis
low density lipoprotein
rheumatoid arthritis patients
ankylosing spondylitis
juvenile idiopathic arthritis
end stage renal disease
ejection fraction
newly diagnosed
dendritic cells
prognostic factors
immune response