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Effects of Antibiotic Interaction on Antimicrobial Resistance Development in Wastewater.

Indorica SutradharCarly ChingDarash DesaiZachary HeinsAhmad S KhalilMuhammad H Zaman
Published in: bioRxiv : the preprint server for biology (2023)
Antimicrobial resistance (AMR) is a growing global threat to public health expected to impact 10 million people by 2050, driving mortality rates globally and with a disproportionate effect on low- and middle-income countries. Communities in proximity to wastewater settings and environmentally contaminated surroundings are at particular risk due to resistance stemming from antibiotic residues from industrial and agricultural runoff. Currently, there is a limited quantitative and mechanistic understanding of the evolution of AMR in response to multiple interacting antibiotic residues in constant flow environments. Using an integrated computational and experimental methods, we find that interactions between antibiotic residues significantly affect the development of resistant bacterial populations.
Keyphrases
  • antimicrobial resistance
  • public health
  • heavy metals
  • wastewater treatment
  • climate change
  • high resolution
  • cardiovascular disease
  • cardiovascular events
  • mass spectrometry
  • anaerobic digestion
  • human health