Pan-Cancer Prevalence of Microsatellite Instability-High (MSI-H) Identified by Circulating Tumor DNA and Associated Real-World Clinical Outcomes.

Pashtoon Murtaza Kasi Leslie A Bucheit Jiemin Liao Jason S Starr Pedro C Barata Samuel J Klempner David R GandaraArdaman ShergillLuciana Madeira da Silva Caroline WeipertNicole ZhangChristopher PretzAaron I Hardin Lesli A KiedrowskiJustin I Odegaard

Published in: JCO precision oncology (2023)

These data support use of a well-validated ctDNA assay to detect MSI-H across solid tumors and suggest prolonged PFS in patients treated with IO-containing regimens after detection. Tumor-agnostic, ctDNA-based MSI testing may be reliable for rapid decision making.

Keyphrases

circulating tumor
loop mediated isothermal amplification
cell free
decision making
circulating tumor cells
papillary thyroid
risk factors
electronic health record
high throughput
squamous cell
squamous cell carcinoma
label free
real time pcr
lymph node metastasis
genetic diversity
artificial intelligence