Human Glioma Cells Acquire Temozolomide Resistance After Repeated Drug Exposure Via DNA Mismatch Repair Dysfunction.
Kei YamashiroKazutaka NakaoShigeo OhbaYuichi HirosePublished in: Anticancer research (2020)
Longer drug treatment may induce resistance of cells to DNA damaging agent(s) by means of mismatch repair modification.
Keyphrases
- circulating tumor
- induced apoptosis
- cell free
- single molecule
- endothelial cells
- cell cycle arrest
- oxidative stress
- adverse drug
- nucleic acid
- pluripotent stem cells
- drug induced
- endoplasmic reticulum stress
- cell death
- signaling pathway
- emergency department
- newly diagnosed
- combination therapy
- circulating tumor cells
- replacement therapy