Diet normalization or caloric restriction as a preconception care strategy to improve metabolic health and oocyte quality in obese outbred mice.
Anouk SmitsWaleed F A MareiDiane De NeubourgJo L M R LeroyPublished in: Reproductive biology and endocrinology : RB&E (2021)
Diet normalization for 4 weeks showed to be the shortest, most promising intervention to improve metabolic health. Most promising improvements in oocyte quality were seen after 6 weeks of intervention in both PCCI groups. This research provides fundamental insights to be considered in developing substantiated preconception guidelines for obese women planning for pregnancy.
Keyphrases
- weight loss
- healthcare
- randomized controlled trial
- public health
- adipose tissue
- quality improvement
- mental health
- physical activity
- metabolic syndrome
- bariatric surgery
- type diabetes
- health information
- pregnancy outcomes
- palliative care
- obese patients
- polycystic ovary syndrome
- health promotion
- clinical practice
- skeletal muscle
- risk assessment
- wild type
- breast cancer risk