Limitations of dual-fluorescent HIV reporter viruses in a model of pre-activation latency.
Youry KimPaul U CameronSharon R LewinJenny L AndersonPublished in: Journal of the International AIDS Society (2020)
Our findings demonstrate that the EF1α promoter has poor constitutive expression in resting CD4+ T cells. Therefore, dual-fluorescent reporter viruses with the EF1α promoter may underestimate the frequency of latent infection in resting CD4+ T cells.
Keyphrases
- heart rate
- dna methylation
- quantum dots
- crispr cas
- heart rate variability
- living cells
- transcription factor
- antiretroviral therapy
- gene expression
- poor prognosis
- hiv positive
- hiv infected
- human immunodeficiency virus
- hepatitis c virus
- hiv testing
- label free
- hiv aids
- men who have sex with men
- blood pressure
- fluorescent probe
- genetic diversity
- south africa