Effects of different phosphate lowering strategies in patients with CKD on laboratory outcomes: A systematic review and NMA.
Nigar SekerciogluArgie Angeliki VeronikiLehana ThabaneJason W BusseNoori Akhtar-DaneshAlfonso IorioLuciane Cruz LopesGordon H GuyattPublished in: PloS one (2017)
We found few differences between treatments in impact on phosphate and differences in parathyroid hormone. Relative to calcium, sevelamer, lanthanum and diet showed significant reduction in serum calcium from baseline. Treatment recommendations should be based on impact on patient-important outcomes rather than on surrogate outcomes. Systematic review registration: PROSPERO CRD-42016032945.