Autoimmune reactivity to malondialdehyde adducts in systemic lupus erythematosus is associated with disease activity and nephritis.

Uta HardtAnders LarssonIva GunnarssonRobert M ClancyMichelle PetriJill P BuyonGregg J SilvermanElisabet SvenungssonCaroline Grönwall

Published in: Arthritis research & therapy (2018)

Elevated IgG anti-MDA in SLE patients was associated with high disease activity, with active lupus nephritis, and with biomarkers of systemic inflammation. This natural antibody reactivity may have potential prognostic utility, and may also actively contribute to pathogenesis.

Keyphrases

disease activity
systemic lupus erythematosus
rheumatoid arthritis
rheumatoid arthritis patients
ankylosing spondylitis
juvenile idiopathic arthritis
end stage renal disease
ejection fraction
newly diagnosed
prognostic factors
multiple sclerosis
signaling pathway
risk assessment
climate change
human health