Long non-coding RNA HOTAIR induces GLI2 expression through Notch signalling in systemic sclerosis dermal fibroblasts.

Christopher W WassonRebecca L RossRebecca WellsClarissa CorinaldesiIoanna Ch GeorgiouNatalia A Riobo-Del GaldoFrancesco Del Galdo

Published in: Arthritis research & therapy (2020)

Our data indicates that GLI2 expression is stably upregulated in SSc myofibroblasts through HOTAIR and that GLI2 mediates the expression of pro-fibrotic markers downstream of Notch.

Keyphrases

poor prognosis
long non coding rna
systemic sclerosis
interstitial lung disease
cell proliferation
binding protein
electronic health record
machine learning
idiopathic pulmonary fibrosis
wound healing