Our study indicates that Scd1, Cidea, Ghr, and Kl are downstream genes regulated by EZH2 in AKI. Upregulation of EZH2 in AKI inhibits the expression of these four genes in a different population of proximal tubular cells to minimize normal physiological function and promote acute or chronic cell injuries following AKI.
Keyphrases
- acute kidney injury
- poor prognosis
- long non coding rna
- ischemia reperfusion injury
- long noncoding rna
- single cell
- genome wide
- induced apoptosis
- liver failure
- oxidative stress
- cell cycle arrest
- drug induced
- bioinformatics analysis
- cell proliferation
- genome wide identification
- signaling pathway
- cell therapy
- respiratory failure
- high fat diet induced
- cell death
- dna methylation
- hepatitis b virus
- aortic dissection
- skeletal muscle
- mesenchymal stem cells
- insulin resistance
- bone marrow
- high glucose