Diverse and highly cross-reactive T-cell responses in ragweed allergic patients independent of geographical region.
Peter Adler WürtzenIlka HoofLars H ChristensenZuzana VáczyHelene HenmarGuillermo SalamancaClaus LundegaardLise LundTatiana KráľovaEdwars G BrooksPeter S AndersenPublished in: Allergy (2019)
T-cell epitopes of multiple allergens/isoallergens are involved in the diverse T-cell responses in ragweed allergic individuals. T-cell lines were highly cross-reactive to epitopes of related ragweed species without any apparent geographical response bias. These data support that different ragweed species can be considered an allergen homology group with Amb a as the representative species regarding diagnosis as well as allergy immunotherapy.
Keyphrases
- end stage renal disease
- allergic rhinitis
- ejection fraction
- newly diagnosed
- chronic kidney disease
- atopic dermatitis
- peritoneal dialysis
- genetic diversity
- prognostic factors
- magnetic resonance imaging
- magnetic resonance
- electronic health record
- big data
- computed tomography
- cross sectional
- patient reported outcomes
- machine learning
- deep learning
- data analysis