Differential Immune Infiltration Profiles in Colitis-Associated Colorectal Cancer versus Sporadic Colorectal Cancer.
Josefine SchardeyCan LuJens NeumannUlrich WirthQiang LiTianxiao JiangPetra ZimmermannJoachim AndrassyAlexandr V BazhinJens WernerFlorian KühnPublished in: Cancers (2023)
In CAC, high CD3+ and CD20+ infiltrates relate to improved survival, while this association is absent in sCRC. The study revealed marked differences in TIGIT and TOX expression, emphasizing distinctions between CAC and sCRC. T-cell exhaustion appears to have a different role in CAC development.