Respiratory complex I regulates dendritic cell maturation in explant model of human tumor immune microenvironment.
Rita TurpinRuixian LiuPauliina M MunneAino PeuraJenna H RannikkoGino PhilipsBram BoeckxNatasha SalmelinElina HurskainenIlida SuleymanovaJuly AungElisa M VuorinenLaura LehtinenMinna MutkaPanu E KovanenLaura NiinikoskiTuomo J MeretojaJohanna MattsonMohamed El MissiryPäivi SaavalainenAndrei GogaDiether LambrechtsJeroen PouwelsMaija HollménJuha KlefströmPublished in: Journal for immunotherapy of cancer (2024)
Our results establish PDECs as a feasible model to identify immunomodulatory functions of anticancer drugs in the context of patient-specific TIME.