Climate warming is expanding dengue burden in the Americas and Asia.

Climate change poses significant threats to public health, with dengue representing a growing concern due to its high existing burden and sensitivity to climatic conditions. Yet, the quantitative impacts of temperature warming on dengue, both in the past and in the future, remain poorly understood. In this study, we quantify how dengue responds to climatic fluctuations, and use this inferred temperature response to estimate the impacts of historical warming and forecast trends under future climate change scenarios. To estimate the causal impact of temperature on the spread of dengue in the Americas and Asia, we assembled a dataset encompassing nearly 1.5 million dengue incidence records from 21 countries. Our analysis revealed a nonlinear relationship between temperature and dengue incidence with the largest marginal effects at lower temperatures (around 15°C), peak incidence at 27.8°C (95% CI: 27.3 - 28.2°C), and subsequent declines at higher temperatures. Our findings indicate that historical climate change has already increased dengue incidence 18% (12 - 25%) in the study region, and projections suggest a potential increase of 40% (17 - 76) to 57% (33 - 107%) by mid-century depending on the climate scenario, with some areas seeing up to 200% increases. Notably, our models suggest that lower emissions scenarios would substantially reduce the warming-driven increase in dengue burden. Together, these insights contribute to the broader understanding of how long-term climate patterns influence dengue, providing a valuable foundation for public health planning and the development of strategies to mitigate future risks due to climate change.