Down syndrome and associated atrioventricular septal defects in a nationwide Norwegian cohort: Prevalence, time trends, and outcomes.

Cecilie Bryn Nordklev Ola Gjesdal Nina Gunnes Henrik HolmstrømNils-Halvdan MorkenSiri Vangen Vasileios Sitras

Published in: Acta obstetricia et gynecologica Scandinavica (2024)

The prevalence of live-born infants with severe CHDs and DS has been stable in Norway across 20 years. Infants with AVSD and DS did not have higher risk of mortality during their first year of life compared to infants with AVSD without chromosomal defects, despite a higher risk of operative intervention.

Keyphrases

risk factors
randomized controlled trial
early onset
cardiovascular events
type diabetes
heart failure
copy number
gene expression
gestational age
metabolic syndrome
hypertrophic cardiomyopathy
low birth weight
skeletal muscle
genome wide